Evidence of latent pathogenesis of Propionibacterium acnes infection in a patient with renal sarcoidosis
نویسندگان
چکیده
A 49-year-old man with pulmonary sarcoidosis was admitted to our hospital because of nephrotic syndrome. Renal biopsy revealed membranous nephropathy and granulomatous interstitial nephritis. DNA and cell membrane constituents of Propionibacterium acnes were detected in the patient’s glomeruli and tubular epithelial cells. Treatment with corticosteroids and an antimicrobial agent resulted in remission of the nephrotic syndrome. This is the second case in which components of P. acnes were found in renal tissue, suggesting latent pathogenesis of P. acnes infection in renal sarcoidosis.
منابع مشابه
Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. Many P. acnes have been detected in sarcoid lymph nodes using quantitative PCR and in sarcoid granulomas by in situ hybridization. P. acnes trigger factor protein causes a cellular immune response only in sarcoid patients and induces...
متن کاملDetermination of antibiotic susceptibility and Minimum Inhibitory Concentration (MIC) of the Propionibacterium acnes to the prevalent antibiotics in the treatment of Acne vulgaris
ABSTRACTPropionibacterium acnes is propounded as one of the significant factors in occurrence of acne. Today, due to development of the antibiotic resistance, most of the acne treatments are faced with failure. In order to determine the antibiotic resistance of the P.acnes strains isolated from the patients with acne, this research has been carried out. 70 samples collected using microbial cult...
متن کاملComplete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient
Propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles and is the only microorganism that has been isolated from sarcoid lesions. We report the complete genome sequence of P. acnes, which was isolated from a Japanese patient with sarcoidosis.
متن کاملGlomerulopathy due to chronic infection of Propionibacterium acnes in a patient with Felty's syndrome.
Felty's syndrome, first reported by Felty in 1924 [1], is well known as a trio of rheumatoid arthritis, splenomegaly, and neutropenia, which occurs in 1-5% of patients with rheumatoid arthritis. The nephropathy associated with Felty's syndrome is very rare; we found only one previous case in the literature [2]. Although the pathogenesis of Felty's syndrome is still unclear, the glomerular lesio...
متن کاملQuantitative analysis of propionibacterial DNA in bronchoalveolar lavage cells from patients with sarcoidosis.
BACKGROUND AND AIM OF THE WORK The causes of sarcoidosis are still unknown. Propionibacterial subspieces are thought to be one of the most likely sources of antigens. Here we attempted to measure the amount of propionibacterial DNA in bronchoalveolar lavage (BAL) cell samples from patients with sarcoidosis and other pulmonary diseases. METHODS We examined BAL cells from 42 patients with sarco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010